By Y. Sawamura, N. de Tribolet (auth.), L. Symon, L. Calliauw, F. Cohadon, B. Guidetti, F. Loew, H. Nornes, E. Pásztor, B. Pertuiset, J. D. Pickard, M. G. Yaşargil (eds.)
As an addition to the eu postgraduate education method for younger neurosurgeons we started to submit in 1974 this sequence dedicated to Advances and Technical criteria in Neurosurgery which used to be later subsidized via the eu organization of Neurosurgical Societies. the truth that the English language is easily with a purpose to changing into the foreign medium at ecu medical meetings is a smart asset when it comes to mutual figuring out. accordingly we now have determined to post all contributions in English, whatever the local language of the authors. All contributions are submitted to the whole editorial board ahead of booklet of any quantity. Our sequence isn't meant to compete with the guides of unique medical papers in different neurosurgical journals. Our goal is, really, to give fields of neurosurgery and comparable parts within which vital contemporary advances were made. The contributions are written through experts within the given fields and represent the 1st a part of each one quantity. within the moment a part of every one quantity, we put up targeted descriptions of ordinary operative tactics, supplied through skilled clinicians; in those articles the authors describe the innovations they hire and clarify the benefits, problems and hazards interested by a number of the tactics. This half is meant basically to help younger neurosurgeons of their submit graduate education. even if, we're confident that it'll even be precious to skilled, totally educated neurosurgeons.
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This quantity studies common remedies for spinal dural arteriovenous fistulas, analyzing the anatomy of arteries and veins of the sylvian fissure, in addition to microsurgical advances and the advance of contemporary healing innovations in intracranial meningiomas. The advances part offers a method for minimizing listening to loss after stereotactic radiosurgery for vestibular schwannomas, in addition to an outline of the mode of motion and biology of ALA, together with its interplay with tumor cells and the bounds of this system.
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A few LAK cells infiltrated into tumor parenchyma (as indicated by arrows in lower-left side of the figure). However there was an active tumor growth next to the site of LAK cells accumulation (Fig. 4 B) 40 Y. SAW AMURA and N. DE TRIBOLET cells, these transferred cells did not migrate preferentially to the site of tumor growth. Furthermore, the postmortem examination in our three autopsied cases also revealed that the LAK cells injected into the cavity surrounding the glioma remained localized at the injection site and did not infiltrate into tumor tissue (Fig.
1975, Trouillas 1970, Young etal. 1977). Steinbok et al. (1984) injected autologous peripheral blood mononuclear cells into the postoperative cavity of four recurrent glioblastoma patients and obtained four autopsies, two of which were performed seven days after the last lymphocyte infusion and one was after three weeks. No lymphocytes were seen in the tumor tissue around the injected site and no significant perivascular lymphocyte accumulations were present in all the glioblastomas. This evidence suggests the inability of adoptively transferred lymphocytes to migrate actively into the autologous tumor tissue.
The production of human MAb to tumor-associated antigens would allow to completely resolve the problem of the human immune response to murine antibodies. The possible application of human MAbs in diagnosis and therapy of cancer has been reviewed by Thompson (1988). 2. Biological Response Modifiers (BRMs) Adjuvant immunotherapy with immunomodulating agents is an attempt to enhance or stimulate the suboptimal immune response of patients with brain malignancies. Early attempts at this type of therapy used the immunization with mycobacteria, either bacille de Calmette-Guerin (BCG) or Corynebacterium parvum.